CelligentCelligent

RNA HPLC method development

HPLC Method Development for RNA Molecules

Fixed-scope methods from structure to report—typically in four weeks or less, with pricing and timeline agreed before work begins.

Discuss your projectHow it works
A NEW MODEL FOR METHOD DEVELOPMENT

Fixed time. Fixed cost.
Zero surprises.

Complete HPLC method development for any RNA molecule — scoped, priced, and delivered in 4 weeks or less. Miss the deadline and you pay 50% less. The timeline is contractual, not aspirational.

Fixed price
One price, agreed before we start. No hourly billing, no surprises.
4weeks max
Any RNA HPLC method — from structure to a finished, reviewable report — in a month or less.
50%back if late
Delivered past the agreed date? Your invoice is cut in half — a guarantee written into every contract.

Celligent vs. the traditional CRO

Others charge for hours worked. We sell you an outcome.

Celligent
Traditional CRO
Pricing
Fixed, agreed up front
Billed per hour
Timeline
≤ 4 weeks, contractual
Open-ended, often months
If it runs late
You pay 50% less
You absorb the overrun
Deliverable
Full report + impurity analysis
Variable, scope-dependent
Focus
RNA HPLC, purpose-built
General analytical services
INCLUDED WITH EVERY METHOD DEVELOPMENT

The complete package

  • Method Development ReportConditions, rationale, system suitability and validation-ready documentation.
  • Complete Impurity AnalysisEvery predicted and observed impurity identified, resolved and characterized.
PREFER YOUR OWN LAB?

Rent our analytical chemists

For fixed-scope projects, our scientists work on-site at your facility — developing and validating the method on your own instruments, to your SOPs. Same fixed price, same fixed timeline, same guarantee.

On your instrumentsTo your SOPsFixed timeline
Scope your project

From Structure to Method

StructureHPLCPredicted impuritiesChromatogram
Agilent 1290 Infinity II

Data stewardship

We work from the structures you share—SMILES, notation, and related analytical inputs—with handling and retention agreed before the project starts.

01

Scope-limited use

SMILES, sequence notation, and chromatographic data are used only to deliver the method development and impurity work defined in your statement of work.

02

Private to your project

Your SMILES, sequences, and related analytical data are handled confidentially—they are not shared with third parties or contributed to a general chemistry or sequence database.

03

Project-based access

Access is limited to the scientists and reviewers assigned to your engagement, with handling practices aligned to common biopharma confidentiality expectations.

04

Clear deliverables

You receive method development documentation and impurity findings in formats intended for internal review, tech transfer, and quality discussion—not marketing summaries.

Discuss your requirements

Frequently Asked Questions

What does Celligent do?
Celligent delivers complete HPLC method development for RNA molecules. Starting from your molecule's structure, we develop and validate a fit-for-purpose method and return a full method development report alongside a complete impurity analysis — all at a fixed cost and a fixed timeline agreed before we begin.
How fast is a method delivered?
Any RNA HPLC method is delivered in 4 weeks or less. The timeline is scoped and agreed up front, and it is contractual — not an estimate. You know your delivery date before the project starts.
What happens if a project runs late?
If we miss the agreed delivery date, you pay 50% less. The penalty is written into every contract, so the deadline is our risk to manage — not yours.
What is included in the deliverable?
Every engagement ships a complete package: a Method Development Report (conditions, rationale, system suitability and validation-ready documentation) and a Complete Impurity Analysis, with every predicted and observed impurity — 5′/3′ n−1, n−2, n+1, PO and related species — identified, resolved and characterized.
How is this different from a traditional CRO?
Traditional CROs bill per hour with open-ended timelines, so cost and schedule are unpredictable. Celligent sells a fixed-price, fixed-timeline outcome (≤4 weeks), backed by a 50% late penalty, and we focus exclusively on RNA HPLC rather than general analytical services.
Which RNA molecules and methods do you cover?
We work across RNA modalities — siRNA, mRNA, ASO, sgRNA and guide RNA — developing IP-RP, AEX and SEC methods for purity, impurity profiling, identity and release testing on standard platforms such as the Agilent 1290 Infinity II.
Can your scientists work in our own lab?
Yes. For fixed-scope projects you can rent our analytical chemists: they work on-site at your facility, developing and validating the method on your own instruments and to your SOPs — with the same fixed timeline and the same guarantee.
How do we get started?
Tell us about your molecule and goal and we'll scope the project, timeline and fixed price up front.
WHAT HAPPENS NEXT

From inquiry to delivered method

A straightforward path—no surprise scope changes after we agree on terms.

  1. 01

    Share your structure

    Tell us about your RNA molecule—SMILES or sequence notation, modality, and what you need from the method (purity, impurities, release, etc.).

  2. 02

    Scoping call

    A short call to align on scope—no obligation. We agree a fixed price and timeline before any work starts.

  3. 03

    Method development

    We develop and document the HPLC method and complete impurity analysis per your statement of work.

  4. 04

    Review & transfer

    You receive reports formatted for internal review, tech transfer, and quality discussion with your team.

GET IN TOUCH

Let's discuss your method development needs

Submit the form below—we typically reply within 1–2 business days. A short scoping call is optional and carries no obligation; fixed scope and pricing are confirmed in writing before work begins.